Monday, December 5, 2011

Putin's party losing support in parliamentary vote

CAPTION CORRECTION CORRECTS THE NAME OF PHOTOGRAPHER - Prime Minister Vladimir Putin, with the emblem of the United Russia party in the background, visits the United Russia party headquarters in Moscow, Saturday, Dec. 4, 2011. Exit polls cited by Russian state television showed Prime Minister Vladimir Putin's party with less than 50 percent of the vote in Sunday's parliamentary elections, a significant drop reflecting Russians' growing weariness with his rule. (AP Photo/RIA Novosti, Alexei Nikolsky, Pool)

CAPTION CORRECTION CORRECTS THE NAME OF PHOTOGRAPHER - Prime Minister Vladimir Putin, with the emblem of the United Russia party in the background, visits the United Russia party headquarters in Moscow, Saturday, Dec. 4, 2011. Exit polls cited by Russian state television showed Prime Minister Vladimir Putin's party with less than 50 percent of the vote in Sunday's parliamentary elections, a significant drop reflecting Russians' growing weariness with his rule. (AP Photo/RIA Novosti, Alexei Nikolsky, Pool)

Elizaveta Semenova is helped by her daughter to fill in a ballot paper at her home in the village of Oster, 380 km (237 miles) west of Moscow, Sunday, Dec. 4, 2011. The ballot box has a sign reading: "Election" and the Smolensk region emblem. Russians cast their ballots with muted enthusiasm in national parliamentary elections Sunday, a vote that opinion polls indicate could water down the strength of the party led by Prime Minister Vladimir Putin, despite the government's relentless marginalization of opposition groups. (AP Photo/Sergei Grits)

Russian soldiers stand in line at a polling station in Moscow, Russia, on Sunday, Dec. 4, 2011. Russians cast their ballots with muted enthusiasm in national parliamentary elections Sunday, a vote that opinion polls indicate could water down the strength of the party led by Prime Minister Vladimir Putin, despite the government's relentless marginalization of opposition groups. (AP Photo/Alexander Zemlianichenko Jr)

Russian Prime Minister Vladimir Putin casts his ballot at a polling station in Moscow, Russia, Sunday, Dec. 4, 2011. Russians cast their ballots with muted enthusiasm in national parliament elections on Sunday, a vote that opinion polls indicate could water down the strength of the country's dominant party. (AP Photo/Ivan Sekretarev)

Russian Prime Minister Vladimir Putin greets journalists after voting at a polling station in Moscow, Russia, Sunday, Dec. 4, 2011. Russians cast their ballots with muted enthusiasm in national parliament elections on Sunday, a vote that opinion polls indicate could water down the strength of the country's dominant party.(AP Photo/RIA Novosti, Alexei Nikolsky, Pool)

(AP) ? Prime Minister Vladimir Putin's party was struggling to reach 50 percent in Russia's parliamentary election, polls and official results showed Sunday, suggesting Russians were wearying of the man who has dominated Russian politics for more than a decade.

Rival parties and election monitors said even this figure was inflated, alleging ballot-stuffing and other significant violations at the polls. Many expressed fears that the vote count would be manipulated.

Putin wanted to see his United Russia party do well in the election as a sign of public support for his return to the presidency in a vote now three months away ? one that he is still expected to win easily.

Putting a positive spin on the disappointing returns, Putin said "we can ensure the stable development of the country with this result," but he appeared glum and limited his remarks to two sentences.

Despite the setback, he was still expected to win the March presidential election and reclaim the position he held from 2000 to 2008. Putin has systematically destroyed any potential challengers. And most Russians do not see any credible alternatives, despite growing dissatisfaction with his strongman style, pervasive official corruption and the gap between ordinary people and the superrich.

United Russia held a two-thirds majority in the outgoing State Duma, which allowed it to change the constitution unchallenged. But it is increasingly disliked, seen as representing a corrupt bureaucracy and known to many as the "party of crooks and thieves."

The Communist Party appeared to be benefiting from the protest vote, with exit polls and the early returns predicting it would get nearly 20 percent, up from less than 12 percent four years ago.

The first official results with more than 25 percent of the vote counted showed about 47 percent for United Russia, compared to 64 percent in 2007. This was in line with an exit poll conducted by the VTsIOM polling agency that had United Russia tallying 48.5 percent and another done by the FOM polling agency that had it winning 46 percent of the vote. The two polls were reported by the two state television channels.

Complete results were expected at 0600 GMT Monday (1 a.m. EDT).

Only seven parties were allowed to field candidates for parliament this year, while the most vocal opposition groups have been denied registration and barred from campaigning.

Several parties complained Sunday of extensive election violations aimed at boosting United Russia's vote count, including party observers being hindered in their work.

Communist chief Gennady Zyuganov said his party monitors thwarted an attempt to stuff a ballot box at a Moscow polling station where they found 300 ballots already in the box before the start of the vote.

He said incidents of ballot-stuffing were reported at several other stations in Moscow, Rostov-on-Don and other areas. In the southern city of Krasnodar, unidentified people posing as Communist monitors had shown up at polling stations and the real observers from the party weren't allowed in, Zyuganov said.

In Vladivostok, voters complained to police that United Russia was offering free food in exchange for promises to vote for the party.

Russia's only independent election monitoring group, Golos, has come under strong official pressure and its website was incapacitated by hackers on Sunday. Golos was still able to field more than 2,000 observers and they reported numerous violations, director Liliya Shibanova said.

She said many of the violations involved absentee ballots, including so-called "cruise voting" where people with the ballots are bused to multiple polling stations. In the Volga River city of Samara, observers and election commission members from opposition parties were barred from verifying that the ballot boxes were properly sealed at all polling stations, Shibanova said.

In Moscow, several journalists, including a photographer for The Associated Press, were briefly detained after taking pictures at a polling station.

Mikhail Kasyanov, a former prime minister during Putin's first presidential term, said he and other opposition activists who voted Sunday are under no illusion that their votes will be counted fairly.

"It is absolutely clear there will be no real count," he said. "The authorities created an imitation of a very important institution whose name is free election, that is not free and is not elections."

A few dozen activists of the Left Front opposition group tried to stage an unsanctioned protest just outside Red Square on Sunday, but were quickly dispersed by police, who detained about a dozen of them. Later in the evening, police said they arrested more than 100 other opposition demonstrators in the capital and about 70 in St. Petersburg when they attempted to hold an unauthorized rally.

The websites of Golos and Ekho Moskvy, a prominent, independent-minded radio station were down on Sunday. Both claimed the failures were due to denial-of-service hacker attacks.

"The attack on the site on election day is obviously connected to attempts to interfere with publication of information about violations," Ekho Moskvy editor Alexei Venediktov said in a Twitter post. The site was back up in the evening.

Golos, which is funded by U.S. and European grants, has come under heavy official pressure in the past week after Putin accused Western governments of trying to influence the election and likened recipients of Western aid to Judas.

Shibanova, the Golos leader, said its hotline was flooded Sunday with automated calls that effectively blocked it. Prior to the vote, many of the group's activists were visited by security agents, while Shibanova was held for 12 hours at an airport and forced to hand over her laptop.

The group had compiled some 5,300 complaints of election-law violations ahead of the vote, most of which were linked to United Russia. Roughly a third of the complainants ? mostly government workers and students ? said their employers and professors were pressuring them to vote for the party.

____

Jim Heintz, Nataliya Vasilyeva and Vladimir Isachenkov contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-12-04-EU-Russia-Election/id-cda5a1b8267b404db2ba28ccfbeb67f6

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Video: Money in Motion

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Sunday, December 4, 2011

PFT: Suh loses appeal on suspension

IMG_4331_large_JPGAP

When the Ravens moved to Baltimore in 1996, the decided to conduct their training camp at nearby McDaniel College, in Westminster, Maryland.

This year, the lockout caused the Ravens to decide to move camp to the team?s facility.? They?ve decided to stay put for training camp in 2012.

?We?ve had long, serious discussions about this decision, and, when all is said and done, we believe we can better prepare for the season by holding training camp here as opposed to McDaniel College or any other facility away from here,? Ravens president Dick Cass said in a release issued by the team. ?We wanted to let the officials at McDaniel and at the hotel [Best Western] know as soon as we made the decision.?

The move, which Cass said wasn?t influenced by financial considerations, apparently is a product of the new labor deal.

?In 1996, Westminster was the best place for us to have training camp,? G.M. Ozzie Newsome said. ?How teams conduct training camp today is vastly different.? Our football needs and requirements are different.? The absence of two-a-days, how much space we need for the players and the meetings, the limited number of practices allowed by the new CBA, the importance of having an indoor field when the summer storms come ? all of that and more football-influenced factors, had me recommend to [owner] Steve [Bisciotti] and Dick that we hold camp here.?

Bisciotti apparently wrestled with the move.? ?From a football and team point of view, it?s an easy decision,? Bisciotti said.? ?Personally, this is difficult.? Some of my best memories as a kid are my family?s visits to the Colts? training camp in Westminster.? Part of my devotion to the game and the players who made it great and are heroes to many of us, started on those visits.

?We completely understand that this takes away an important part of our connection with our fans. I regret that,? Bisciotti added.? ?Hopefully, we can find other ways to continue this outreach.? We?ll have more to say on this as we develop these programs.?

It?ll be interesting to see whether other teams follow suit, abandoning the traditional training camp experience for the facility to which the players report to work throughout the year.? The reasons articulated by the Ravens should apply to every team that currently has an off-site camp.? Time will tell whether more and more of them come to that same conclusion.

Source: http://profootballtalk.nbcsports.com/2011/12/02/ndamukong-suh-loses-his-appeal/related

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Saturday, December 3, 2011

Lions' Suh crashes car in Portland; not injured

(AP) ? Police in Oregon say Detroit Lions defensive tackle Ndamukong Suh crashed his car into a tree in downtown Portland, but was not injured.

Police say Suh was not impaired and was cooperative with officers following the accident at about 1:15 a.m. Saturday. Suh lost control of the 1970 Chevrolet Coupe he was driving, which then hit a curb, light pole, drinking fountain and tree. His vehicle was towed from the scene.

Suh had two passengers in the vehicle. They were not injured.

Suh is a graduate of Portland's Grant High School. He was the NFL's 2010 defensive rookie of the year. On Tuesday, the league suspended him for two games for stomping the arm of Packers guard Evan Dietrich-Smith.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2011-12-03-FBN-Suh-Car-Crash-/id-7e6582d685384b2b85c0799f601dcefb

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Diametric shift in 2 protein levels spurs Alzheimer's plaque accumulation

Thursday, December 1, 2011

A diametric shift in the levels of two proteins involved in folding, moving and cutting other proteins enables accumulation of the destructive brain plaque found in Alzheimer's disease, researchers report.

VPS35 is a protein that folds others into specific positions to unleash their functions. When levels are reduced as they are in aging, it unleashes the normally dormant BACE1, a protein responsible for beta amyloid plaque production, Georgia Health Sciences University researchers report in The Journal of Cell Biology.

When researchers modified a mouse model of Alzheimer's so that VPS35 production was essentially cut in half, BACE1 activity was increased, accelerating aging and development of related problems such as memory deficits and poor communication between brain cells as well as beta amyloid accumulation, said Dr. Wen-Cheng Xiong, developmental neurobiologist and Weiss Research Professor at GHSU and the study's corresponding author.

It was known that expression of VPS35 was down and BACE1 was up in Alzheimer's but the direct relationship was unknown, Xiong said. "We believe impaired function of VPS35 could be a risk factor for Alzheimer's and Parkinson's diseases," Xiong said. Discovering the relationship makes VPS35 a potential biomarker for the diseases as well as a target for new therapies to keep VPS35 elevated. The accelerated aging model Xiong developed and patented will enable these future drug studies.

This unhealthy balance causes cells to accumulate more waste than their recycling systems can handle. Additionally misfolded proteins end up in the wrong cell compartment where they form aggregates that eventually kill the cell. Being in the wrong place is what enables BACE1 activity to increase: it ends up stuck in a cell compartment called the endosome where high acidity levels activate the protein. As BACE1 becomes more numerous and active, it chops up more potentially productive proteins, turning them into garbage.

"Each protein knows its destination, lifespan and when it should be degraded; everything is controlled. With aging, their trafficking, their control system is disrupted," Xiong said.

Future questions include what reduces VPS35 levels, such as increased levels of reactive oxygen species that come with age, and whether exercise can help keep them up. 'We think VPS35 will be a new, hot and hopefully productive area for Alzheimer's and Parkinson's research," Xiong said.

The protein is classified a retromer. Retromers are important to recycling inside cells. While silent in healthy adults, BACE1 plays an important role in brain development.

###

Georgia Health Sciences University: http://www.georgiahealth.edu

Thanks to Georgia Health Sciences University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/115648/Diametric_shift_in___protein_levels_spurs_Alzheimer_s_plaque_accumulation

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Friday, December 2, 2011

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Well hello

Well, hello. I've been registered for some time now, but for a long time my computer wouldn't let me log on. Not through lack of trying, I assure you.

Right, for the questions.

1) What's your username? Why'd you pick that username?

My username is Lither. I picked it because I once thought up a random name for a wiki registration, and it kinda stuck onto me, then mutated into its own personality :P.

2) How'd you find this place? Google? Why'd you look it up on Google or whatever?

I was interested in a site devoted to PbP RPing.

3) How long have you roleplayed on forums or chat? On what sites? Did you start with tabletop games or such?

*Whistles* A very long time on forums and IRL. I think I started out playing D&D on the tabletop with a few friends.

4) In coming to RPG, what've you been looking for specifically? A new home for roleplay? Better roleplay?

I've been looking for a better place to roleplay.

5) What kinds of roleplay are you interested in? Fantasy? Sci-fi? Go in-depth about it if you want.

I'm interested in most roleplays aside from the romantic ones - more because I'm fairly bad at it than any other reason for disliking it.

Funny roleplays I especially enjoy.

6) What're your hobbies? Do you collect rocks or mount insects?

I enjoy studying philosophy. I also enjoy drawing with Inkscape, and I hope to be able to create my own (internet) game within a few years.

7) What's something you're good at besides writing? Maybe you're on the volleyball team or you're a quick learner? Maybe you play the flute or can fold up chairs amazingly fast? xD

I'm very good at mass-repeating bear puns. It's so bad, nobody around me can bear even mentioning bears. They find it quite un-bear-able.

I also am good at self-deprecation.

8) Do you have any friends here at RPG that invited you here? Would you want to make more friends while you're here?

I don't have friends who invited me here. I would be interested in making new ones, however.

9) Do we get cookies for looking through your thread and saying hello?

No. The cookies are also lies.

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/rbarSpushdY/viewtopic.php

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